Polymeric Microspheres For Synthesis And Immobilisation

SpheriTide™ polymeric microspheres for solid phase synthesis consist of poly-ε-lysine cross-linked with multifunctional carboxylic acids. The peptidic nature of the polymer backbone is probably the optimum environment to assemble a peptide by solid phase chemistry ultimately forming a true quasi-homogeneous peptide-gel network.

The polymer capacities displayed in the following tables are a guideline. The precise loading is defined in the data sheet for each batch.

SpheriTide™ KS

KS is cross-linked with sebacic acid to provide a solid support with excellent solvation and handling properties. In particular this polymer does not have the tendency to stick to the walls of solid phase reactors which is often observed with other hydrophilic solid supports such as polyethylene glycol and polydimethylacrylamide based polymers.

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SpheriTide™ KN

KN is cross-linked with nitrilotriacetic acid to provide a solid support with a tertiary base at the centre of each cross-linking function. This has the potential to provide an internal catalyst for amide bond formation but also has the ability to be pre-swollen by conversion to a 1-hydroxybenzotriazole salt which may impart advantages for assembly of difficult peptide sequences.

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